Arachidonate Metabolism of Vascular Cell

Arachidonate metabolism in vascular disorders.

Vascular Effects of Arachidonate

2. Scheuer J, Stezoski SW: Effect of high energy phosphate depletion and repletion on the dynamics and electrocardiogram of isolated rat hearts. Circ Res 23: 519 530, 1968 3. Rovelto M J, Whitmer JT, Neely J R: Comparison of the effects of anoxia and whole heart ischemia on carbohydrate utilization in isolated working rat hearts. Circ Res 32: 699-711, 1973 4. Williamson JR: Glycolytic control m...

Poxvirus-induced alteration of arachidonate metabolism.

Recent evidence suggests that orthopoxviruses have an obligate requirement for arachidonic acid metabolites during replication in vivo and in vitro. Our report indicates that a virus family (Poxviridae) possesses multiple genes that function to regulate arachidonate metabolism. Analyses of BS-C-1 cells infected with cowpox virus or vaccinia virus detected enhanced arachidonate product formation...

Macrophage-dependent arachidonate metabolism in hydronephrosis.

Unilateral ureteral obstruction in rabbits leads to an influx of macrophages into the kidney, a proliferation of interstitial cells, and an increase in arachidonic acid metabolism. The role of the macrophage in the metabolic changes of hydronephrosis was investigated by using endotoxin and nitrogen mustard. The in vivo administration of endotoxin, a macrophage agonist, 1 hour before perfusion o...

Arachidonate metabolism by human polymorphonuclear leukocytes

Release of arachidonic acid by the membrane phospholipase and metabolism by the 5-lipoxygenase pathway was examined in human polymorphonuclear leukocytes (PMNs). The 5-lipoxygenase pathway is activated when PMNs are given arachidonic acid in ethanol and there is extensive metabolism to 5-hydroxyicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). This activation event was shown to be altere...